Motor behavior of APP/PS1 KI and wild-type control mice. (A) No differences in grip strength are observed between amyloid precursor protein/presenilin-1 knock-in (APP/PS1 KI) mice and their wild-type (WT) counterparts in any age group. (B) No performance differences are observed between APP/PS1 KI and WT mice for any age group in the beam walk task. (C), (D) Open field performance shows no significant differences in ambulatory movement, as assessed by (C) distance traveled or(D) movement velocity, between APP/PS1 KI and WT mice for any age group. (E) Rotor rod performance shows no differences between APP/PS1 KI and WT mice for any age group. However, performance is negatively correlated with weight (E insert) for the WT animals (P = 0.004) and is almost significantly correlated for APP/PS1 KI mice performance (P = 0.052). Number of mice: 10 WT and nine KI mice aged 7 months; five WT and eight KI mice aged 11 months; eight WT and eight KI mice aged 15 months; and eight WT and five KI mice aged 24 months.