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Table 3 Risk factors for dementia in the oldest old

From: Dementia in the oldest old: a multi-factorial and growing public health issue

Associated with increased dementia risk No clear association with dementia risk Equivocal, more research needed
Low level of education APOE E4 allele Late-life dyslipidemia
Poor mid-life healtha APOE E2 allele Late-life diabetes
Low level of physical activity   Late-life elevations in C-reactive protein or other inflammatory markers
Delirium   Late-life hypertension
Depression   
  1. APOE, apolipoprotein E. aLow grip-strength, overweight/obesity, hypertriglyceridemia, hyperglycemia, hypertension, excessive alcohol intake, smoking.