Weight of APP/PS1 mice and their age-matched wild type control mice. Mice were injected with saline and D-Ala2 glucose-dependent insulinotropic polypeptide (GIP) at 6 months of age. Mice were weighed one day before injections started and every 5 days over a period of 30 days. (A) Body weight at 6 months. Data represent mean ± standard error of the mean (SEM) of 14 wild type (WT) mice per group and 12 APP/PS1 mice per group (two-way analysis of variance, ANOVA). (B) Body weight at 12 months. Data represent mean ± SEM of 11 WT mice injected with saline, 12 WT mice injected with D-Ala2GIP and 11 APP/PS1 per group (two-way ANOVA).