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Table 1 Pharmacokinetic properties of SPI-1865 in mouse and rat

From: Efficacy of SPI-1865, a novel gamma-secretase modulator, in multiple rodent models

Species Volume (L/kg)2 Brain/plasma (24 h)1 T1/2 (h)2 Tmax
Mouse 9.2 0.4 to 1.4 8.3 approximately 4 hrs
Rat 5.8 0.5 to 1.5 129 6 to 8 hrs
  1. The pharmacokinetic properties of SPI-1865 were assessed in both mouse and rat. 1Based on various oral dosing regimens; 2Volume and T1/2 values are based on intravenous drug delivery data. T1/2, half-life; Tmax, time of maximum concentration.