SPI-1865 dose-responsively lowers β-amyloid (Aβ)
after a single oral dose. Sprague Dawley rats were orally administered a single dose of SPI-1865 of 10, 30 or 100 mg/kg. Plasma and brain were harvested 24 hrs post dose and analyzed for compound, Aβ38, Aβ40, and Aβ42 levels. Data are graphed as a percent of vehicle control. *P-value < 0.01 based on analysis of variance (Dunnett's test).