Table 4 Longitudinal studies in populations including sporadic Alzheimer's disease patients
From: Plasma amyloid beta measurements - a desired but elusive Alzheimer's disease biomarker
| Study | Subjects | Mean age at baseline (years) | Duration of follow-up (years) | Platform and antibodies | CV | Analyte associated with increased risk conversion to AD | Magnitude |
|---|---|---|---|---|---|---|---|
| Mayeux et al. 1999 [30] |
105 CNs 64 CNp |
73.4 77.4 | 3.5 |
ELISA 6E10 R182 R165 | - | High baseline Aβ1-42 | HR = 3.6-4.0 |
| Mayeux et al. 2003 [27] |
365 CNs 86 CNp |
75.5 79.3 |
ELISA 6E10 R182 R165 | - | High baseline Aβ1-42 | 1.9-2.4 | |
| van Oijen et al. 2006 [61] |
1364 CNs 289 CNp 103 CNp-OD | 8.5 |
ELISA 6E10 R226 R209 | <15% |
High baseline Aβ1-40 Low baseline Aβ1-42/Aβ1-40 |
HR = 1.17 HR = 1.82 | |
| Graff-Radford et al. 2007 [58] |
510 CNs 53 CNp | - | 5 |
ELISA BAN-50 BA27 BC05 | - | Low baseline Aβ1-42/Aβ1-40 | RR = 2.47-3.08 |
| Lopez et al. 2008 [63] |
117 CNs 115 CNp 9 MCIs 33MCIp |
78.6 79.9 80.5 79.6 | 4.5 | ELISA | - | None | - |
| Sundelöf et al. 2008 [62] |
608CNs 74 CNp | - | 11.2 |
ELISA BNT77 BA27 BC05 | - | Low baseline Aβ1-40 (only in the cohort older than 77 at baseline) | HR = 4.9 |
| Schupf 2008 [57] | 104 MCIp 1021 CNs |
80.7 76.3 | 4.5 |
ELISA 6E10 R182 R165 | - | High baseline Aβ1-42 Decrease of Aβ1-42 Decrease of Aβ1-42/Aβ1-40 |
HR = 2.3-3.5 HR = 2.6 HR = 3.4 |
| Lambert et al. 2009 [59] |
985 CNs 233 CNp |
73.8 77.9 | 4 | xMAP INNO-BIA | - | Low baseline Aβ1-42/Aβ1-40 | HR = 2.0 |
| Blasko et al. 2010 [78] |
122 CNs 33 CNp | - | 5 | ELISA INNOTEST | <17% | High baseline Aβ1-42 | OR = 1.7 |
| Hansson et al. 2010 [13] | xMAP INNO-BIA | <10% | No differences | ||||
| Toledo et al. 2011 [10] |
162 MCIs 145 MCIp |
74.7 74.6 | 3.0 | xMAP INNO-BIA | <10% | None | |
| Shah et al. 2012 [60] |
590 CNs 53 MCIp 24 MCIp-VaD | - | 15.8 | ELISA 2G3 21F12 | <20% |
Low baseline Aβ1-40 Low baseline Aβ1-42 |
HR = 2.1 HR = 1.6 |
| Hansson et al. 2012 [29] |
677 CNs 37 MCIp 11 MCIp-VaD 5 MCIp-OD |
73.1 77.3 78.9 78.8 | 5 | xMAP INNO-BIA | <10% | High baseline Aβ1-40 | OR = 2.2 |