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Figure 2 | Alzheimer's Research & Therapy

Figure 2

From: Memantine in patients with Alzheimer's disease receiving donepezil: new analyses of efficacy and safety for combination therapy

Figure 2

Meta-analyses of change from baseline to endpoint in individual domains of Alzheimer's disease (LOCF analysis). aModerate to severe (AD) (MMSE 5 to 19 at baseline), receiving donepezil (10 mg/day). bModerate AD (MMSE 10 to 19 at baseline), receiving donepezil (10 mg/day). AD, Alzheimer's disease; ITT, intention-to-treat; LOCF, last observation carried forward; SMD, standardised mean difference; SIB, Severe Impairment Battery; ADAS-Cog, AD Assessment Scale-cognitive subscale; ADCS-ADL19/23, 19-/23-item AD Cooperative Study-Activities of Daily Living scale; CIBIC-Plus, Clinician's Interview-Based Impression of Change Plus Caregiver Input.

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