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Figure 5 | Alzheimer's Research & Therapy

Figure 5

From: Clinical, imaging, and pathological heterogeneity of the Alzheimer's disease syndrome

Figure 5

Frontal variant Alzheimer's disease. A 57 year old woman presenting with mild short-term memory loss and inability to perform simple daily and occupational tasks. Prominent frontal symptoms were noted 2 years into the course of her illness, with prominent apathy, loss of empathy, and socially inappropriate behaviours. Axial T1 MRI at the level of the basal ganglia (left), done 1 year after symptom onset, demonstrated mild frontal atrophy with increased sulcal markings (white arrows). Axial single-photon emission computed tomography (SPECT) done within a few months at the same level (right) demonstrated frontal hypoperfusion, especially on the left (red arrows). The patient died 5 years after the start of her symptoms, and autopsy revealed Alzheimer's disease (Braak V/VI).

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