Temporal variant Alzheimer's disease. A 69 year old woman presenting with short-term memory loss and very slow progression with conversion to mild dementia about 5 years later. Her last neuropsychological testing after 11 years of follow-up revealed normal language and visuospatial function, with very mild executive dysfunction and significant impairment on memory items. Ten years into her course, imaging including coronal T1 MRI at the level of the hippocampus (bottom left) demonstrated marked hippocampal atrophy (white arrows) while single-photon emission computed tomography (SPECT) done at the same time (bottom right) showed mesiotemporal hypoperfusion (red arrows). Axial T1 MRI (top left) and SPECT (top right) at the level of the basal ganglia demonstrated no atrophy in the parietal and frontal association areas and no hypoperfusion in the same areas.