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Table 1 Characteristics of subjects

From: Plasma lipoprotein-associated phospholipase A2 activity in Alzheimer's disease, amnestic mild cognitive impairment, and cognitively healthy elderly subjects: a cross-sectional study

Characteristic

AD

(n= 78)

aMCI

(n= 59)

Normal Control

(n= 66)

P*

Demographic

    

   Age, y (mean, SD)

75.7 (8.4)

71.3 (8.5)

71.1 (8.3)

0.0005

   Female, N (%)

47 (60%)

28 (43%)

24 (36%)

0.017

   Education, y (mean, SD)

11.4 (2.8)

12.8 (3.5)

13.1 (2.7)

0.0005

Clinical

    

   Statin Use, N (%)

16 (21%)

17 (28.8%)

11 (17%)

0.26

   BMI (mean, SD)

25.4 (3.2)

25.6 (3.9)

24.6 (3.7)

0.33

   ESC score (mean, SD)

0.133 (0.110)

0.094 (0.102)

0.103 (0.078)

0.015

   Diabetes type 1 or 2, N (%)

6 (7.7%)

1 (1.7%)

3 (4.5%)

0.30

   History of heart disease, N (%)

8 (10.3%)

9 (15.3%)

7 (10.6%)

0.68

   Hachinski score (mean, SD)

2.6 (1.9)

2.5 (2.6)

0.7 (1.0)

< 0.0001

   Scheltens score (mean, SD)

12.2 (9.9)

10.8 (10.8)

6.4 (5.7)

0.0021

   Wahlund score (mean, SD)

4.0 (2.7)

3.7 (2.8)

2.8 (1.7)

0.04

   Duration of symptoms, y (mean, sd)

2.5 (2.4)

3.1 (3.3)

NA

0.63

   MMSE, mean (mean, SD)

23.8 (2.7)

28 (1.7)

29.1 (1.0)

< 0.0001

Laboratory

    

   LpPLA2, nmol/min/ml (mean, SD)

197.1 (38.4)

205.5 (43.4)

195.4 (41.9)

0.34

   LDL, mmol/L (mean, SD)

2.9 (1.0)

2.9 (0.8)

3.0 (1.2)

0.79

   HDL, mmol/L (mean, SD)

2.0 (0.5)

1.8 (0.5)

1.7 (0.5)

0.005

   Total cholesterol:HDL ratio

3.0 (0.9)

3.2 (0.9)

3.5 (1.2)

0.012

   Homocysteine, Umol/L (mean, sd)

15.1 (5.4)

14.1 (7.9)

12.3 (3.4)

0.002

   HbA1c, % (SD)

5.6 (0.4)

5.6 (0.4)

5.5 (0.3)

0.43

CSF markers of AD

    

   Aβ42, pg/ml (mean, SD)

421.4 (147.6)

568.2 (251.7)

809.7 (260.5)

< 0.0001

   CSF T-Tau, pg/ml (mean, SD)

698.5 (317.2)

417.2 (245.6)

308.0 (195.9)

< 0.0001

   CSF P-Tau, pg/ml (mean, SD)

101.9 (58.0)

62.9 (27.9)

52.0 (21.6)

< 0.0001

Genetic

    

   APOE ε4-positive, N (%)

45 (58%)

30 (50.5%)

4 (6%)

NA†

  1. *ANOVA for normally distributed continuous variables, Kruskal-Wallis test for non-normal continuous variables, Fisher's exact test for ordinal variables. † Control selection was not independent of APOE status.