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Table 2 Compartment parameters.

From: Simulations of symptomatic treatments for Alzheimer's disease: computational analysis of pathology and mechanisms of drug action

Current m α β x ∞ τ x (ms)  
Pyr - Naf 3 - 0 . 2816 ( V + 28 ) - 1 + exp ( - ( V + 28 ) / 9 . 3 ) 0 . 2464 ( V + 1 ) - 1 + exp ( ( V + 1 ) / 6 ) α α + β 1 α + β  
  1 0 . 098 exp ( ( V + 43 . 1 ) / 20 1 . 4 1 + exp ( - ( V + 13 . 1 ) / 10 ) α α + β 1 α + β  
Pyr - Kdr 4 - 0 . 018 ( V - 13 ) - 1 + exp ( - ( ( V - 13 ) / 25 ) ) 0 . 0054 ( V - 23 ) - 1 + exp ( ( V - 23 ) / 12 ) α α + β 1 α + β  
Pyr - Nap 1 - 0 . 2816 ( V + 17 ) - 1 + exp ( - ( V + 17 ) / 9 . 3 ) 0 . 2464 ( V - 10 ) - 1 + exp ( ( V - 10 ) / 6 ) α α + β 1 α + β  
  1 0.00002exp ( - V + 42 . 8477 4 . 0248 ) 0 . 014286 1 + exp ( - V - 413 . 9284 148 . 2589 ) α α + β 1 α + β  
Pyr - HVA 2 - - 1 1 + exp ( - V + 24 . 6 11 . 3 ) 1.25 sech(0.031(V + 37.1))  
  2 - - 1 1 + exp ( - V + 12 . 6 18 . 9 ) 420  
Pyr - Ks 1 - - 1 1 + exp ( - V + 34 6 . 5 ) 6  
  1 - - 1 1 + exp ( - V + 65 6 . 6 ) 200+ 3200 1 + exp ( - ( V + 63 . 6 ) / 4 )  
Pyr - KCa 2 - 0 . 00642 ( V s + 18 ) - 0 . 1152 - 1 + exp ( - ( V s + 18 ) / 12 ) 1.7exp ( - V s + 152 30 ) α α + β max ( 1 α + β , 1 . 1 )  
   V s = V + 40 log10(104[Ca++] i )     
Int - Naf 3 4.2exp ( V + 34 . 5 11 . 57 ) 4.2exp ( - V + 34 . 5 27 ) α α + β 1 α + β  
  1 0.09exp ( - V + 45 33 ) 0.09exp ( - V + 45 12 . 2 ) α α + β 1 α + β  
Int - Kdr 4 0.3exp ( V + 35 10 . 67 ) 0.3exp ( - V + 35 42 . 68 ) α α + β 1 α + β  
  1. Gating functions [11] used for the membrane currents in the model neurons. The cell type and current are listed at the left, and the column head ins refer to Eq 5: gating exponent (m), gating variables (α and β), the equilibrium activation(inactivation) (x∞), and the activation(inactivation) time constant (τ x ).
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Alzheimer's Research & Therapy

ISSN: 1758-9193