Figure 2

Schematic diagram of the connectivity and receptors in the prefrontal cortex network. Schematic diagram of the connectivity and receptors in the prefrontal cortex network. The position of different types of cholinergic (M₁, α₇, α₄β₂), dopaminergic (D₁, D₄), serotonergic (5-HT_1A, 5-HT_2A, 5-HT₃), noadrenergic (α_2A), glutamate and GABA receptors is shown according to their preclinical data. The memory stimulus (M) is given at 2 sec into the simulation and represents a sensory or conceptual stimulus that is introduced into the network. The background noise (B) represents the interaction of this particular network with the rest of the cortex and the brain and is described as a Poisson process and is present throughout the simulation.