From: NF-κB-regulated, proinflammatory miRNAs in Alzheimer's disease
Human miRNA | mRNA target | mRNA function | Result of mRNA or gene expression deficit | References |
---|---|---|---|---|
miRNA-125b | CDKN2A | Cyclin-dependent kinase inhibitor 2A cell cycle inhibitor; induces cell cycle arrest | Downregulation of cell cycle control: glial cell proliferation | |
miRNA-125b | SYN-2 | Synapsin-2: neuronal synaptic phosphor-protein; coats synaptic vesicles; functions in the regulation of neurotransmitter release | Impairment of neurotransmitter release; synaptic signaling deficits | |
miRNA-125b | 15-LOX-1 | ALOX15; arachidonate 15-lipoxygenase; essential in the conversion of docosahexaenoic acid to neuroprotectin D1 (NPD1) | Deficit in neurotrophic omega-3 fatty acid derivatives in the brain | |
miRNA-146a | CFH | Complement factor H; repressor of activation of the innate immune response in brain and retina at the C3 to C3b transition; deficits in disease are proinflammatory | Defect in control of the innate immune response; chronic stimulation of the innate immune response and proinflammatory signaling | |
miRNA-146a | IRAK-1 | Interleukin-1 receptor-associated kinase 1; initiation of the innate immune response and NF-κB signaling | Compensatory surge in IRAK-2 and chronic stimulation of NF-κB signaling in the brain | |
miRNA-146a | TSPAN12 | Transmembrane 4 superfamily member 12; regulator of cell surface receptor signal transduction; activates ADAM10-dependent cleavage activity of βAPP | Results in a shift from neurotrophic (sAPPα) to amyloidogenic (Aβ42 peptide) processing of βAPP |