Figure 1

Representative magnetic resonance images for the three most common frontotemporal dementia (FTD)-causing gene mutations. T1-weighted magnetic resonance images are shown for three different patients, each harboring a single mutation in a different gene that causes FTD. The patient with MAPT demonstrates symmetrical atrophy in ventral frontotemporal regions, particularly in the anterior temporal poles, whereas the GRN mutation carrier demonstrates marked asymmetrical atrophy, most notable in dorsal, frontotemporal regions, with additional involvement in posterior areas. However, the patient with C9ORF72 expansion shows diffuse, symmetrical atrophy in frontal, temporal, and parietal cortical regions as well as cerebellum. C9ORF72, chromosome 9 open reading frame 72; GRN, granulin; MAPT, microtubule-associated protein tau.