Table 2 Individual patient and group brain magnetic resonance imaging volumetric data

Age at first scan

63.0

59.2

65.6

70.6

66.8

50.7

62.7 (7.0)

58.7 (5.8)

Gender (male:female)

5:1

10:5

Disease duration (years)

2.9

4.2

7.6

2.6

18.8

2.7

6.5 (6.3)

N/A

Interscan interval (years)

0.9

1.2

1

0.6

1.1

1.1

1.0 (0.2)

1.6 (0.8)

Total intracranial volume (ml)

1,624

1,835

1,854

1,368

1,686

1,465

1,639 (196)

1,610 (144)

Brain volume, baseline (ml)

1,171

1,351

1,290

876

1,232

1,076

1,166 (171)

1,231 (92)

Brain volume, repeat (ml)

1,146

1,344

1,293

842

1,179

1,072

1,146 (179)

1,226 (92)

Volume change (ml)

25

7

-3

34

53

4

20 (22)

5 (17)

Left hemisphere, baseline (ml)

592

675

651

433

623

542

586 (88)

614 (56)

Left hemisphere, repeat (ml)

579

675

653

415

592

538

575 (93)

611 (53)

Right hemisphere, baseline (ml)

589

686

646

451

619

542

589 (84)

612 (60)

Right hemisphere, repeat (ml)

576

681

648

433

595

541

579 (87)

609 (54)

Ventricle volume, baseline (ml)

44.4

38.2

35.0

40.3

27.8

21.8

34.6 (8.4)

21.4 (11.4)

Ventricle volume, repeat (ml)

47.7

39.0

37.9

44.8

29.8

26.2

37.6 (8.3)

22.5 (12.2)

Brain BSI (%/year)

1.1

-0.2

0.5

4.4

1.0

1.6

1.4 (1.6)

0.4 (0.3)

Ventricle expansion (ml/year)

3.6

0.8

2.5

6.2

1.6

4.3

3.2 (2.0)

0.7 (0.6)

Cerebellar BSI (%/year)

-0.5

-0.2

0.6

1.9

1.8

2.6

1.0 (1.3)

0.1 (0.5)

Left hemisphere rate (%/year)

2.4

0.1

-0.4

6.9

4.6

0.6

2.4 (2.9)

0.5 (1.3)

Right hemisphere rate (%/year)

2.4

0.6

-0.2

6.2

3.7

0.1

2.1 (2.5)

0.5 (1.0)