|
Age at first scan
|
63.0
|
59.2
|
65.6
|
70.6
|
66.8
|
50.7
|
62.7 (7.0)
|
58.7 (5.8)
|
|
Gender (male:female)
| | | | | | |
5:1
|
10:5
|
|
Disease duration (years)
|
2.9
|
4.2
|
7.6
|
2.6
|
18.8
|
2.7
|
6.5 (6.3)
|
N/A
|
|
Interscan interval (years)
|
0.9
|
1.2
|
1
|
0.6
|
1.1
|
1.1
|
1.0 (0.2)
|
1.6 (0.8)
|
|
Total intracranial volume (ml)
|
1,624
|
1,835
|
1,854
|
1,368
|
1,686
|
1,465
|
1,639 (196)
|
1,610 (144)
|
|
Brain volume, baseline (ml)
|
1,171
|
1,351
|
1,290
|
876
|
1,232
|
1,076
|
1,166 (171)
|
1,231 (92)
|
|
Brain volume, repeat (ml)
|
1,146
|
1,344
|
1,293
|
842
|
1,179
|
1,072
|
1,146 (179)
|
1,226 (92)
|
|
Volume change (ml)
|
25
|
7
|
-3
|
34
|
53
|
4
|
20 (22)
|
5 (17)
|
|
Left hemisphere, baseline (ml)
|
592
|
675
|
651
|
433
|
623
|
542
|
586 (88)
|
614 (56)
|
|
Left hemisphere, repeat (ml)
|
579
|
675
|
653
|
415
|
592
|
538
|
575 (93)
|
611 (53)
|
|
Right hemisphere, baseline (ml)
|
589
|
686
|
646
|
451
|
619
|
542
|
589 (84)
|
612 (60)
|
|
Right hemisphere, repeat (ml)
|
576
|
681
|
648
|
433
|
595
|
541
|
579 (87)
|
609 (54)
|
|
Ventricle volume, baseline (ml)
|
44.4
|
38.2
|
35.0
|
40.3
|
27.8
|
21.8
|
34.6 (8.4)
|
21.4 (11.4)
|
|
Ventricle volume, repeat (ml)
|
47.7
|
39.0
|
37.9
|
44.8
|
29.8
|
26.2
|
37.6 (8.3)
|
22.5 (12.2)
|
|
Brain BSI (%/year)
|
1.1
|
-0.2
|
0.5
|
4.4
|
1.0
|
1.6
|
1.4 (1.6)
|
0.4 (0.3)
|
|
Ventricle expansion (ml/year)
|
3.6
|
0.8
|
2.5
|
6.2
|
1.6
|
4.3
|
3.2 (2.0)
|
0.7 (0.6)
|
|
Cerebellar BSI (%/year)
|
-0.5
|
-0.2
|
0.6
|
1.9
|
1.8
|
2.6
|
1.0 (1.3)
|
0.1 (0.5)
|
|
Left hemisphere rate (%/year)
|
2.4
|
0.1
|
-0.4
|
6.9
|
4.6
|
0.6
|
2.4 (2.9)
|
0.5 (1.3)
|
|
Right hemisphere rate (%/year)
|
2.4
|
0.6
|
-0.2
|
6.2
|
3.7
|
0.1
|
2.1 (2.5)
|
0.5 (1.0)
|
