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Table 2 Individual patient and group brain magnetic resonance imaging volumetric data

From: Longitudinal neuroimaging and neuropsychological profiles of frontotemporal dementia with C9ORF72 expansions

  Case 1 Case 2 Case 3 Case 4 Case 5 Case 6 C9ORF72 Controls
Age at first scan 63.0 59.2 65.6 70.6 66.8 50.7 62.7 (7.0) 58.7 (5.8)
Gender (male:female)        5:1 10:5
Disease duration (years) 2.9 4.2 7.6 2.6 18.8 2.7 6.5 (6.3) N/A
Interscan interval (years) 0.9 1.2 1 0.6 1.1 1.1 1.0 (0.2) 1.6 (0.8)
Total intracranial volume (ml) 1,624 1,835 1,854 1,368 1,686 1,465 1,639 (196) 1,610 (144)
Brain volume, baseline (ml) 1,171 1,351 1,290 876 1,232 1,076 1,166 (171) 1,231 (92)
Brain volume, repeat (ml) 1,146 1,344 1,293 842 1,179 1,072 1,146 (179) 1,226 (92)
Volume change (ml) 25 7 -3 34 53 4 20 (22) 5 (17)
Left hemisphere, baseline (ml) 592 675 651 433 623 542 586 (88) 614 (56)
Left hemisphere, repeat (ml) 579 675 653 415 592 538 575 (93) 611 (53)
Right hemisphere, baseline (ml) 589 686 646 451 619 542 589 (84) 612 (60)
Right hemisphere, repeat (ml) 576 681 648 433 595 541 579 (87) 609 (54)
Ventricle volume, baseline (ml) 44.4 38.2 35.0 40.3 27.8 21.8 34.6 (8.4) 21.4 (11.4)
Ventricle volume, repeat (ml) 47.7 39.0 37.9 44.8 29.8 26.2 37.6 (8.3) 22.5 (12.2)
Brain BSI (%/year) 1.1 -0.2 0.5 4.4 1.0 1.6 1.4 (1.6) 0.4 (0.3)
Ventricle expansion (ml/year) 3.6 0.8 2.5 6.2 1.6 4.3 3.2 (2.0) 0.7 (0.6)
Cerebellar BSI (%/year) -0.5 -0.2 0.6 1.9 1.8 2.6 1.0 (1.3) 0.1 (0.5)
Left hemisphere rate (%/year) 2.4 0.1 -0.4 6.9 4.6 0.6 2.4 (2.9) 0.5 (1.3)
Right hemisphere rate (%/year) 2.4 0.6 -0.2 6.2 3.7 0.1 2.1 (2.5) 0.5 (1.0)
  1. Rates of whole brain, hemispheric and ventricular change. Group data show the mean (standard deviation). BSI, boundary-shift integral; C9ORF72, chromosome 9 open reading frame 72; N/A, not applicable.