Table 1 Options for enrichment and measuring progression in pre-mild cognitive impairment and mild cognitive impairment
| Â | Â | Enrichment | |
|---|---|---|---|
| Â | Â | Biomarkers/DNA markers | Clinical measures |
Measuring progression | Biomarkers | Biomarker not validated as outcome | Clinical measures are too variable, and biomarker is not validated as outcome. |
| Â | Clinical outcomes | Best option | Measurement error leads to potential issues with regression toward the mean. |