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Table 1 Options for enrichment and measuring progression in pre-mild cognitive impairment and mild cognitive impairment

From: Measuring clinical progression in MCI and pre-MCI populations: enrichment and optimizing clinical outcomes over time

   Biomarkers/DNA markers Clinical measures
Measuring progression Biomarkers Biomarker not validated as outcome Clinical measures are too variable, and biomarker is not validated as outcome.
  Clinical outcomes Best option Measurement error leads to potential issues with regression toward the mean.