Figure 5
From: Overlapping profiles of Aβ peptides in the Alzheimer's disease and pathological aging brains
Mass spectrometric (MS) analysis following immunoprecipiation of Aβ peptides from 70% formic acid extracted lysates of human subjects. 70% formic acid extracted lysates of Alzheimer's disease (AD; A, D), pathological aging (PA; B, E) and control (NDC; C, F) cohorts were subjected to immunoprecipitation with pull-down by Ab9 (A-C), sequential pull-down with Ab9 and 4G8 (D-F). Representative MS spectra are shown. Peaks corresponding to Aβ peptides have been labeled according to m/z. Aβ1-28 was spiked in as an experimental control. Different peaks corresponding to modified Aβ are shown (4-42*, Aβ4-42 + 16 Da; 1-40*, Aβ1-40 +16 Da; 1-42**, Aβ1-42 + 22 Da). Aβ, amyloid β.