Figure 1
From: Overlapping profiles of Aβ peptides in the Alzheimer's disease and pathological aging brains
Immunohistochemical characterization of amyloid and tau pathology in Alzheimer's disease (AD), pathological aging (PA) and normal non-demented controls (NDC). A-E. Representative paraffin embedded formalin fixed hippocampi from human AD (A, B), PA (C, D) and control (NDC; E) subjects were stained with 33.1.1 antibody (pan Aβ1-16). Insets show higher magnification with special emphasis on cored Aβ plaques associated with blood vessels in subjects with a post-mortem clinical pathological diagnosis of cerebral amyloid angiopathy (CAA+). Scale Bar, 600 μm (A-E), insets 60 μm (A-E). F-J. Representative paraffin embedded formalin fixed hippocampi from human AD (F, G), PA (H, I) and NDC (J) subjects were stained with anti-phosphorylated tau (CP13). Insets highlight phorphorylated tau containing tangles and neuritic structures. Scale Bar, 600 μm (A-E), insets 60 μm (A-E). Aβ, amyloid β.