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Table 1 The levels of Aβ in the brains of mice of each genotype and age

From: Reduction of low-density lipoprotein receptor-related protein (LRP1) in hippocampal neurons does not proportionately reduce, or otherwise alter, amyloid deposition in APPswe/PS1dE9 transgenic mice

Age (month) Cre N Aβ40 (pg/mg brain) Aβ42 (pg/mg brain) ratio 40/42
    Average STDEV.P P -value Average STDEV.P P -value  
8 - 3 1,257 1,022 0.40 271 193 0.45 4.6
  + 3 481 315   142 75   3.4
9 - 17 2,024 1,192 0.90 399 192 0.71 5.1
  + 12 2,074 746   421 116   4.9
15 - 4 4,235 946 0.65 1,015 104 0.74 4.2
  + 4 4,582 823   972 188   4.7
16 to 18 - 4 4,445 1,135 0.74 971 181 0.79 4.6
  + 5 4,830 1,777   1,020 289   4.7
  1. There was no difference in the levels of Aβ40 and 42 in the brains of mouse expressing APPswe/PS1dE9 gene in the LRP1 lox/lox homozygous background in the absence or presence of the GFAP-Cre transgene in any given age group.
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Alzheimer's Research & Therapy

ISSN: 1758-9193