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Figure 4 | Alzheimer's Research & Therapy

Figure 4

From: Reduction of low-density lipoprotein receptor-related protein (LRP1) in hippocampal neurons does not proportionately reduce, or otherwise alter, amyloid deposition in APPswe/PS1dE9 transgenic mice

Figure 4

LRP1 is below the level of detection in astrocytes. The same sets of mice described in the legend to Figure 2 were immunostained. LRP1 α377 antibody (1:1,000, red) was used for LRP1 staining and antibody to GFAP (1:1,000, green) was used to mark astrocytes. Reactive astrocytes could be seen around amyloid plaques in APPswe/PS1dE9 × LRP1lox/lox (right column) but these cells did not show detectable levels of LRP1. Immunoreactivity to LRP1 was evident within the plaque as neuritic profiles. LRP1 immunostaining in these neuritic structures was diminished in most hippocampal amyloid plaques of APPswe/PS1dE9 × LRP1lox/lox × GFAP-Cre mice (left column).

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Alzheimer's Research & Therapy

ISSN: 1758-9193