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Figure 1 | Alzheimer's Research & Therapy

Figure 1

From: Relationships between the amyloid precursor protein and its various proteolytic fragments and neuronal systems

Figure 1

A limited map of amyloid precursor protein relationships showing molecules/neuronal systems as nodes and interactions between them as arrows. Evidence for each relationship is summarised in Table 2. Numbers are referred to in the text. Aβ, amyloid beta protein; Abl, tyrosine-protein kinase ABL1; AChR, acetylcholine receptor; ADAM, a disintegrin and metalloproteinase domain-containing protein; AICD, APP intracellular domain; Akt, RAC-alpha serine/threonine-protein kinase; AMPAR, AMPA receptor; ApoE, apolipoprotein E; APP, amyloid precursor protein; BACE, beta-site amyloid precursor protein cleaving enzyme; CD74, HLA class II histocompatibility antigen gamma chain; ECM, extracellular matrix; IDE, insulin degrading enzyme; JIP1, C-Jun-amino-terminal kinase-interacting protein 1; JNK, C-Jun amino-terminal kinase; Lyn, tyrosine-protein kinase Lyn; PKA, protein kinase A; PKC, protein kinase C; LRP, low-density lipoprotein receptor; LTP, long-term potentiation; mAChR, muscarinic acetylcholine receptor; mGluR, metabotropic glutamate receptor; nAChR, nicotinic acetylcholine receptor; NMDAR, NMDA receptor; P2Y2, P2Y purinoceptor 2; PI3K, phosphoinositide 3-kinase; sAPP, secreted amyloid precursor protein; Src, proto-oncogene tyrosine-protein kinase Src; TIMP, tissue inhibitor of metalloproteinases; TNF, tumour necrosis factor.

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