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Table 4 Standardized odds ratios of p-tau, t-tau, Aβ42, p-tau/Aβ42, nHV, and prior ICH in relation to global cognition (normal vs impairment), episodic memory (normal vs impairment) and psychiatric symptoms (no vs \(\ge\) 1) in patients with sCAA

From: The relation of a cerebrospinal fluid profile associated with Alzheimer’s disease with cognitive function and neuropsychiatric symptoms in sporadic cerebral amyloid angiopathy

Global cognition (impairment vs normal; corrected for ICH; n=54)

 

Standardized odds ratio (95% CI)

p-value

p-tau

0.79 (0.44-1.40)

0.42

t-tau

0.74 (0.42-1.32)

0.31

Aβ42

2.71 (0.87-8.45)

0.09

p-tau/Aβ42 ratio

0.61 (0.32-1.15)

0.13

nHVb

4.37 (1.49-12.80)

0.007

ICHa

1.97 (0.47-8.27)

0.35

Episodic memory (impairment vs normal; corrected for ICH; n=53)

 p-tau

0.99 (0.53-1.82)

0.97

 t-tau

0.90 (0.50-1.63)

0.74

 Aβ42

0.98 (0.53-1.83)

0.95

 p-tau/ Aβ42 ratio

1.05 (0.57-1.97)

0.89

 nHVb

3.62 (1.30-10.10)

0.014

 ICHa

0.98 (0.25-3.80)

0.98

Psychiatric symptoms ( \(\ge\) 1 vs 0 symptom(s); corrected for ICH; n=54)

 p-tau

0.69 (0.38-1.27)

0.23

 t-tau

0.75 (0.41-1.35)

0.33

 Aβ42

1.92 (0.95-3.88)

0.07

 p-tau/ Aβ42 ratio

0.55 (0.27-1.09)

0.08

 nHVb

1.34 (0.67-2.66)

0.40

 ICHa

0.33 (0.08-1.41)

0.14

  1. aNot corrected for ICH, bBIONIC only; n = 38 sCAA. Aβ42 = CSF amyloid beta-42. CI Confidence interval, CSF Cerebrospinal fluid, ICH Intracerebral haemorrhage, p-tau CSF phosphorylated tau, t-tau CSF total tau, nHV normalized hippocampal volume