Cognitive training and cognitive rehabilitation for persons with mild to moderate dementia of the Alzheimer's or vascular type: a review
© BioMed Central Ltd 2013
Published: 7 August 2013
Cognitive impairments, and particularly memory deficits, are a defining feature of the early stages of Alzheimer's disease and vascular dementia. Interventions that target these cognitive deficits and the associated difficulties with activities of daily living are the subject of ever-growing interest. Cognitive training and cognitive rehabilitation are specific forms of non-pharmacological intervention to address cognitive and non-cognitive outcomes. The present review is an abridged version of a Cochrane Review and aims to systematically evaluate the evidence for these forms of intervention in people with mild Alzheimer's disease or vascular dementia. Randomized controlled trials (RCTs), published in English, comparing cognitive rehabilitation or cognitive training interventions with control conditions and reporting relevant outcomes for the person with dementia or the family caregiver (or both), were considered for inclusion. Eleven RCTs reporting cognitive training interventions were included in the review. A large number of measures were used in the different studies, and meta-analysis could be conducted for several primary and secondary outcomes of interest. Several outcomes were not measured in any of the studies. Overall estimates of the treatment effect were calculated by using a fixed-effects model, and statistical heterogeneity was measured by using a standard chi-squared statistic. One RCT of cognitive rehabilitation was identified, allowing the examination of effect sizes, but no meta-analysis could be conducted. Cognitive training was not associated with positive or negative effects in relation to any of the reported outcomes. The overall quality of the trials was low to moderate. The single RCT of cognitive rehabilitation found promising results in relation to some patient and caregiver outcomes and was generally of high quality. The available evidence regarding cognitive training remains limited, and the quality of the evidence needs to improve. However, there is still no indication of any significant benefits from cognitive training. Trial reports indicate that some gains resulting from intervention may not be captured adequately by available standardized outcome measures. The results of the single RCT of cognitive rehabilitation show promise but are preliminary in nature. Further well-designed studies of cognitive training and cognitive rehabilitation are required to provide more definitive evidence. Researchers should describe and classify their interventions appropriately by using the available terminology.
Cognitive impairment is a defining feature of dementia caused by neurodegenerative conditions such as Alzheimer's disease (AD) and cerebrovascular disease. In the milder stages of dementia, cognitive impairments are often the most disabling and distressing features for the individual and their family. For the person with dementia, memory and other cognitive difficulties can have a major impact on levels of confidence and can lead to anxiety, depression, and withdrawal from activities, which in turn can result in 'excess disability' . Family caregivers are also affected because of the practical impact of cognitive problems on everyday life and the strain and frustration that often result. Interventions to assist with aspects of cognitive functioning, such as memory problems, and associated functional limitations are therefore important in the milder stages of dementia as they may allow the person greater independence and can potentially minimize the risk of 'excess disability'. Interventions for people with mild dementia can be pharmacological, non-pharmacological, or both. Within the broader context of non-pharmacological interventions for people with mild dementia, there has been a steady increase in interest in the class of interventions generally referred to as cognition-focused interventions, and these form the focus of the present review.
Although extensive efforts to develop disease-modifying treatments continue, consistently disappointing results from drug trials with various agents have led to considerable doubt that disease-modifying treatments can show a positive effect by the time dementia is fully developed , and efforts in this direction are increasingly being shifted to the pre-dementia or even the pre-symptomatic stage. In contrast, non-pharmacological interventions, and particularly cognition-based interventions, are increasingly being recognized as an important adjunct (and, in some cases, alternative) to pharmacological treatments for individuals with dementia and those at risk of dementia. Nevertheless, earlier studies suggested that cognition-based interventions are not appropriate, as they are ineffective and result in frustration and depression for participants and caregivers . With a growing emphasis on early detection and intervention in dementia care, the need for a clear evidence base for cognition-focused interventions is therefore becoming increasingly apparent .
Cognition-focused interventions are interventions that directly or indirectly target cognitive functioning as opposed to interventions that focus primarily on behavioral (for example, wandering), emotional (for example, anxiety), or physical (for example, sedentary lifestyle) function. Several types of cognition-based interventions have been described. The potential benefits of reality orientation and of non-specific stimulation of cognitive functioning for people with dementia have long been recognized. These interventions typically involve engaging the person with dementia in a range of general activities and discussions, are commonly conducted in groups, and are aimed at general enhancement of cognitive and social functioning. A recent Cochrane Review that focuses on interventions falling under this category concluded that general cognitive stimulation and reality orientation approaches consistently produce improvements in general cognition and, in some cases, in self-reported quality of life and well-being, primarily for people with mild to moderate dementia .
Progress in understanding the operation of memory and related cognitive functions and of the mechanisms underpinning learning has facilitated the development of more specific approaches designed to help maintain or enhance cognitive functioning and well-being for people with AD or vascular dementia (VaD), most commonly those in the milder stages. These more recent approaches to cognition-based interventions are most commonly referred to as cognitive training (or 'retraining' or 'remediation' or 'brain training') or cognitive rehabilitation. The present review focuses on these two more recent forms of cognition-based interventions. A more detailed review is published and regularly updated in the Cochrane Database of Systematic Reviews (CDSR) . Because the terms cognitive training and cognitive rehabilitation traditionally have been applied somewhat interchangeably in the literature, Clare and colleagues [7, 8] have previously offered the following broad definitions and descriptions with the aim of clarifying the nature of these two related but distinct forms of intervention. Cognitive training typically involves guided practice on a set of standardized tasks designed to reflect particular cognitive functions, such as memory, attention, or problem solving. Tasks may be presented in paper-and-pencil [9–11] or computerized [12–14] form or may involve analogs of activities of daily living [15–17]. Tailoring of task difficulty on the basis of the individual performance level and adaptive training (that is, adjustment of task difficulty in response to change in performance level) is becoming increasingly available through computerized packages (for example, ). One assumption underlying cognitive training is that practice has the potential to improve or at least maintain functioning in the given domain. An additional assumption is that any effects of practice will generalize beyond the immediate training context. Although this latter assumption has not often been supported by the evidence [19, 20], some have argued that the failure to produce transferable benefits is related in part to problems with task design . Recently, some have broadened the definition of cognitive training to include strategy training, which involves the instruction and practice of strategies to minimize cognitive impairment and enhance performance (for example, method of loci and visual imagery) and cognitive exercise . Cognitive training may be offered through individual [10, 16] or group [23, 24] sessions or facilitated by family members [17, 25] with therapist support. In accordance with the suggestion that cognitive training may enhance the effects of pharmacological therapy , some studies have evaluated the efficacy of cognitive training in combination with acetylcholinesterase-inhibiting [11, 16, 24] or other [12, 27] medications. In addition, cognitive training for persons with dementia has sometimes been included as a component of supportive interventions for caregivers .
Historically, rehabilitation has been viewed as a process aimed at helping people achieve or maintain an 'optimal level of physical, psychological and social functioning' in the context of specific impairments arising from illness or injury , thus facilitating participation in preferred activities and valued social roles . More recent views of rehabilitation include a deeper appreciation of the complex interplay between disease and ability to function: a disability may persist even once the disease that triggered it has been eliminated, and likewise disability can be reduced in the face of permanent injury or chronic disease . Cognitive rehabilitation, originally developed mainly through work with younger brain-injured people but equally applicable to progressive conditions, refers to the rehabilitation of people with cognitive impairments. Although the concept continues to evolve, cognitive rehabilitation generally refers to an individualized approach to helping people with cognitive impairments, in which those affected, and their families, work together with health-care professionals to identify personally relevant goals and devise strategies for addressing these . The emphasis is not on enhancing performance on cognitive tasks as such but on improving functioning in the everyday context. Cognitive rehabilitation interventions aim to tackle directly those difficulties considered most relevant by the person with dementia and his or her family members or supporters and target everyday situations in the real-life context. Cognitive rehabilitation approaches tend to be implemented in real-world settings since there is no implicit assumption that changes instituted in one setting would necessarily generalize to another. Goals for intervention are selected collaboratively, and interventions are usually conducted on an individual basis.
Selected differences between cognitive training and cognitive rehabilitation
Structured tasks and environments
Focus of intervention
Isolated cognitive abilities and processes
Groups of cognitive abilities and processes required to perform everyday tasks
Individualized or group
Proposed mechanism of action
Mainly restorative; sometimes combined with psychoeducation and strategy training
A combination of restorative and compensatory approaches combined with psychoeducation and strategy training
Improved or maintained ability in specific cognitive domains
Performance and functioning in relation to collaboratively set goals
Cognition-based interventions for persons with acquired disorders of the central nervous system (including traumatic brain injury, stroke, and neurodegenerative conditions) are driven by knowledge of brain-behavior relationships and mechanisms of injury, disease, and recovery. Historically, such interventions reflected two broad conceptual frameworks to the recovery of function following brain illness or injury: a traditional or restorative approach and a contextualized or compensatory approach . Techniques usually associated with cognitive training - such as the repeated exercise of standardized cognitive tests of increasing difficulty, targeting specific cognitive domains - tend to reflect restorative principles and 'thrive on the lure of neuroplasticity' . Some evidence in support of this comes from a recent functional magnetic resonance imaging (fMRI) study that showed increased memory-related brain activation following cognitive training in several brain regions of individuals at high risk of dementia due to mild cognitive impairment (MCI) . Such increased brain activation may be the result of processes of synaptic growth and repair triggered by repeated practice on standardized tests. On the other hand, techniques usually associated with cognitive rehabilitation, such as using strategies to optimize residual cognitive abilities in impaired domains and making the most of unimpaired cognitive abilities, lend themselves more to compensatory approaches. For example, in relation to memory and learning, it is well established that the processes of memory encoding and consolidation, and the subsystem of declarative memory, tend to be profoundly impaired even in the milder stages of AD . Nevertheless, research has shown that, given appropriate conditions and support and sufficient time, people with dementia still have the ability to learn and retain some information and skills despite their memory difficulties [37–39]. A cognitive rehabilitation approach may focus on helping the person with dementia and their families make the most of residual memory ability (for example, by identifying the best ways of taking in important information [40–43] or carrying out important real-life practical skills ). Indeed, several learning principles and techniques (for example, errorless learning and spaced retrieval) have been found to lead to improved rates of learning and memory among patients with mild dementia [45, 46]. Importantly, it is also well documented that despite the severity of memory difficulties, certain memory systems and processes - such as implicit memory (for example, priming and procedural memory) - are relatively preserved in the milder stages of AD and VaD [47, 48]. This profile suggests that interventions may also aim to build on areas of relative strength reflected in preserved aspects of memory and work with patients on strategies to learn information via less impaired components of the memory system. Finally, cognitive rehabilitation interventions also attempt to assist patients in developing ways to compensate for impairments in those aspects of memory that are significantly affected (such as the use of external memory aids or making environmental changes), so as to minimize the cognitive demand of various activities [49–51]. Cognitive rehabilitation interventions use these and other techniques to enhance or maintain everyday functioning and well-being and reduce excess disability for the person with dementia and to reduce strain for family caregivers.
The primary objective of this review was to evaluate the evidence regarding the effects of cognitive training and cognitive rehabilitation for people with mild to moderate AD or VaD in relation to cognitive and non-cognitive outcomes for the person affected and their caregiver. In addition, we consider the nature and quality of the randomized controlled trial (RCT) evidence that is available on this topic.
This review is an abridged version of a regularly maintained and recently updated Cochrane Review on the topic. For a detailed description of the review methodology, readers are referred to the complete version in the CDSR. Central elements of the methodology are summarized below.
To be considered for inclusion, studies had to be RCTs of cognitive training or cognitive rehabilitation (consistent with the definitions provided above) for individuals with mild to moderate AD or VaD and had to be published in English. Interventions could be delivered individually or in groups, with or without the inclusion of family caregivers. At a minimum, studies had to include pre- and post-intervention assessments using standardized measures.
Cognitive and non-cognitive outcomes for the person with dementia (for example, performance on objective measures by cognitive domain, self-rated cognitive functioning, mood, well-being, and quality of life).
Outcomes for the primary caregiver (mood, burden of care, quality of life, and so on).
Effects of the intervention on the course of dementia (global dementia severity and rates of admission to residential care).
Outcomes of studies of cognitive training and of cognitive rehabilitation were considered separately. In addition, separate comparisons were conducted for outcomes in the short term (that is, the first assessment after intervention) and, where available, the medium (2 to 12 months after intervention) and long (>12 months) term. To contribute to the meta-analysis of a given outcome, studies had to have measured the outcome with at least one standardized measure or questionnaire.
The Cochrane Dementia and Cognitive Improvement Group's Specialized Register ALOIS  - was most recently searched on 2 November 2012. ALOIS is maintained by the Trials Search Co-ordinator of the Cochrane Dementia and Cognitive Improvement Group and contains studies in the areas of dementia prevention, dementia treatment, and cognitive enhancement in healthy individuals. For a comprehensive list of sources included in the ALOIS database, readers are referred to the ALOIS website .
Data collection and analysis
The latest search results (covering the period of April 2006 to November 2012) were reviewed by AB-F, who identified all relevant RCTs of cognition-based interventions in mild AD or VaD and retrieved the full texts. Two review authors (AB-F and LC) independently reviewed each article to determine whether inclusion criteria were met. There were no disagreements regarding the inclusion of studies. All relevant data were extracted from the studies selected for inclusion, recorded in a data-entry form, and entered into Review Manager (RevMan) for statistical analyses. Additional information was sought from study authors as appropriate. Change from baseline statistics was calculated from the group means and standard deviations at baseline, post-intervention, and follow-up. The meta-analysis was conducted on change-from-baseline scores. Outcome measures were treated as continuous measures. In some cases, outcomes were derived from ordinal rating scales; provided that these contained a reasonably large number of categories (>10), the data were treated as continuous variables arising from a normal distribution.
The mean difference with 95% confidence intervals was used whenever studies used the same outcome measure, and the standardized mean difference, which is the absolute mean difference divided by the pooled standard deviation, was used when the same outcome was assessed using different measures. Overall estimates of the treatment effect were calculated with a fixed-effects model by using the inverse variance method.
Statistical heterogeneity was assessed by using a standard chi-squared statistic and associated l2 statistic. Consistent with recommendations, heterogeneity was deemed to be present when the chi-squared statistic was significant at a P value of 0.1 or the l2 suggested that more than 40% of the variability in effect estimate was due to heterogeneity . As no evidence of statistical heterogeneity was found, all analyses were conducted by using a fixed-effects model.
Selected features of the included studies
Age in years, mean (SD or SE)
Education, mean (SD)
Beck et al.  (1988)
Intervention (n = 10): cognitive skills remediation training
Control (n = 10): no treatment
18 sessions of 30-40 minutes, 3 times a week for 6 weeks
75 (SD not reported)
Data reported in frequencies
Differences in favor of the experimental group were found on one measure of memory (recall of digits).
Heiss et al.  (1994)
Intervention (n = 18): computerized cognitive training targeting memory, perception, and motor skills
Control (n = 17): social support
48 × 60-minute sessions, twice a week for 24 weeks
Improved cognitive and brain activation outcomes were reported for the group that received cognitive training combined with pharmacological treatment (not included in the analyses).
Quayhagen et al.  (1995)
Intervention (n = 25): cognitive training facilitated by caregiver targeting memory, problem-solving, and conversational fluency, combined with weekly home visits by therapist
Control (n = 25): wait-list control
72 × 60-minute sessions for 12 weeks
73.6 (SD not specified)
At the follow-up assessment, participants in the experimental condition were at or around baseline on cognitive and behavioral measures, whereas the control group showed further decline.
De Vreese et al.  (1998)
Intervention (n = 9): cognitive training targeting memory, language, and executive functions, combined with home practice facilitated by the caregiver
Control (n = 9): placebo medication
24 × 45-minute sessions for 12 weeks
Benefits on both the cognitive and non-cognitive outcomes were observed in the group that received a combination of Ach-I and cognitive training (not included in the analyses).
Quayhagen et al.  (2000)
Intervention (n = 21): cognitive training delivered by the caregiver with therapist support and targeting memory, problem-solving, and conversational fluency
Control (n = 15): wait-list control treatment
40 × 60-minute sessions for 8 weeks
74.5 (SE = 0.7)
14.5 (SE = 0.3)
At the 3-month follow-up assessment, only participants in the cognitive training group showed significant improvement in their scores on composite cognitive measures (delayed memory and verbal fluency). Caregivers of patients in this group had lower depressive symptoms.
Davis et al.  (2001)
Intervention (n = 19): cognitive training targeting face-name associations and recall using spaced retrieval, combined with home practice on attention training exercises
Control (n = 18): active control intervention consisting of weekly clinic visits involving unstructured conversation and questioning with the examiner as well as viewing health-related videos
5 × 60-minute sessions for 5 weeks
Participants in the cognitive training group improved on trained tasks. However, no differences between the groups were observed on any of the untrained outcome measures.
Koltai et al.  (2001)
Intervention (n = 16): memory and coping program in individual (n = 8) or group (n = 8) sessions. The program included training and practice in strategies of spaced retrieval, face-name recall, verbal elaboration, concentration/ overt repetition, use of external memory aids, and ways of coping. Where available, caregivers joined the last 10 to 15 minutes of each session.
Control (n = 8): wait-list control
5-6 × 60-minute sessions for 5-6 weeks
Trends favoring the cognitive training group were observed, but no comparison reached statistical significance.
Cahn-Weiner et al.  (2003)
Intervention (n = 17): cognitive training program to improve word-list recall and recognition
Control (n = 17): active control group receiving didactic presentations but no formal memory training
6 × 45-minute sessions for 6 weeks
No group differences were found on any of the outcome measures.
Loewenstein et al.  (2004)
Intervention (n = 25): cognitive training targeting face-name associations, orientation, attention, procedural memory, calculating change during purchase, and paying bills
Control (n = 19): an active, cognitive stimulation group engaged in generic computer games as well as in word games and exercises and in conversations about recent and distant topics
24 × 45-minute sessions for 12-16 weeks
Participants in the cognitive training group improved in their performance on tasks analogous to the ones used during training to a greater extent than the mental stimulation group. There were no group differences on any of the untrained tasks.
Galante et al.  (2007)
Intervention (n = 7): computerized cognitive training targeting various cognitive domains
Control (n = 4): active control group involving participants attending sessions that included a semi-structured interview/conversations focused on current affairs in meaningful life events
12 × 60-minute sessions, 3 times per week for 4 weeks
Participants in the control group have shown a decline in Mini-Mental State Examination scores over the 9 months of the study, whereas participants in the cognitive training group remained stable by the end of the study period. No other differences were observed.
Neely et al.  (2009)
Intervention (n = 10): cognitive training facilitated by a therapist focusing on strategies to support everyday mnemonic and occupational performance. The cognitive training group employed spaced retrieval to practice a face-name task and hierarchical cueing to practice both a table-setting activity and the face-name task.
Control (n = 10): no-treatment group
8 × 60-minute sessions for 8 weeks
No differences between the individual cognitive training group and the control group were observed on any of the outcome measures.
Clare et al.  (2010)
Intervention (n = 22): cognitive rehabilitation targeting patient-derived personal goals. Sessions were supported by components addressing practical aids and strategies, techniques for learning new information, practice in maintaining attention, and techniques for stress management.
Control (n = 22): no-treatment group
8 × 60-minute sessions for 8 weeks
Participants in the cognitive rehabilitation group have shown a significant improvement in their rating of goal performance and satisfaction as well as increased or preserved activation in several brain regions.
The meta-analysis revealed no differences between cognitive training and control conditions on any of the primary or secondary outcomes included in the analyses. The great majority of comparisons were conducted by using the standardized mean difference method because of the heterogeneity of measures used for each outcome. Depending on the specific analysis, standardized mean differences between cognitive training and control conditions ranged from −0.11 to 0.31. Furthermore, the evidence from cognitive training interventions to date was generally judged to be of low to moderate quality. Longer-term outcomes related to the trajectory of dementia (that is, severity of dementia and rates of admission to residential care) were not assessed in any of the included studies.
Because only a single trial of cognitive rehabilitation  met criteria for inclusion in the review, no meta-analysis could be conducted. Clare and colleagues  found that cognitive rehabilitation was superior to the control condition in relation to a number of outcomes in the short term (patient-reported improvement in goal performance and satisfaction immediately after intervention) and in the medium term (greater satisfaction with memory performance 6 months after intervention). There was also evidence that caregivers of participants in the cognitive rehabilitation group had improved social relationships following the intervention relative to the control condition. Finally, a subset of participants showed changes in task-related brain activation on fMRI following cognitive rehabilitation . This trial was judged to be at relatively low risk of bias in all domains considered and hence to be of generally high quality.
Summary of main results
The aim of this updated review was to evaluate the current evidence regarding the efficacy of cognitive training and cognitive rehabilitation interventions for people with mild AD or VaD. Eleven studies of cognitive training were identified for inclusion in the review (and nine of these were included in the previous version of this review), and meta-analysis was performed on several primary and secondary outcomes in the short and medium term. No positive or adverse effects of cognitive training were detected in the meta-analysis. The finding of no adverse effects of cognitive training is relevant in light of proposals from previous commentators (for example, ) that cognitive training may have a negative impact, particularly on mood. Only one RCT of individualized cognitive rehabilitation was identified. Hence, no meta-analysis could be conducted.
Overall completeness and applicability of evidence
Number of publications meeting inclusion criteria
Since the publication of the previous version of the Cochrane Review, only two additional RCTs that investigated cognitive training in patients with AD or VaD and that met the review criteria were published [14, 17]. In addition, only a single study met our inclusion criteria for individualized cognitive rehabilitation. Several factors appear to account for the small number of new studies that met criteria for the present review. First, insufficient methodological quality, namely non-randomized trials, led to the exclusion of several published trials (for example, [59, 60]) from the review. Second, several RCTs of cognition-based interventions either did not meet our definitions of cognitive training and cognitive rehabilitation or described multi-component interventions (for example, [61, 62]). Issues related to the inclusion criteria used in the present review are further discussed below. A third factor that may have contributed to the appearance of a smaller number of relevant studies in the literature is associated with the widely held belief that interventions - pharmacological and non-pharmacological alike - have the greatest chance of success when applied in the earliest possible stage of AD or VaD. Hence, in recent years, studies have increasingly targeted individuals who do not meet criteria for dementia but who nevertheless show significant cognitive decline - such as persons with amnestic mild cognitive impairment [63, 64]. Indeed, many of the records that were retrieved in the updated literature search now focus exclusively on individuals with MCI, and separate reviews focusing on individuals with MCI have been published [65, 66].
Issues related to the inclusion of randomized controlled trials only
The original protocol of the Cochrane Review on which this article is based  stated that only RCTs would be included in the review. RCTs have long been regarded as the highest form of evidence in medical research because of the lower risk of bias associated with them. However, most of the studies of cognitive training included in the present review were rated as having substantial risk of bias in several domains, and the quality of evidence was low to moderate. Hence, although the more recent studies are generally of a higher methodological quality and this trend is likely to continue, it might be justifiable, under strict conditions, to include high-quality non-randomized trials in future reviews to increase the evidence base from which conclusions can be drawn. There are several possible advantages of including high-quality non-randomized trials in a systematic review, and the pooled estimates of effect sizes from randomized and non-randomized trials can be analyzed separately .
Issues related to definitions of interventions and multi-component interventions
Despite some progress in the application of a clearer and more consistent terminology to refer to various cognition-based interventions in mild dementia, interventions often continue to be inaccurately labeled. Specifically, studies continue to be published in which interventions are described as cognitive training or as cognitive rehabilitation while they in fact appear to more closely reflect cognitive stimulation or reality orientation (for example, ). This state of affairs means that it was generally insufficient, in reviewing the available literature and choosing studies to include in the review, to examine the title used in the publication, and in many cases, the Methods section of a published trial had to be closely scrutinized to clarify whether the actual intervention was consistent with the one suggested by the title.
In addition, the present review excluded trials in which an intervention was described as a combination of elements from various approaches - such as cognitive behavior therapy combined with elements of cognitive rehabilitation (for example, ). This decision is related to the fact that different techniques are likely to have different mechanisms of action and that it is generally not possible in such interventions to isolate the contribution of different components to the measured outcomes. The definitions of cognition-based interventions provided in this review essentially reflect groups of intervention techniques that tend to go together, but there is also some overlap in the techniques used in cognitive stimulation, training, and rehabilitation (for example, psychoeducation may be a component of each of these approaches). Because each of these broad approaches to intervention is likely to involve the use of more than one intervention technique with different mechanisms of action (for example, setting goals, learning effective methods to learn new information, and repeated practice), these approaches can also be regarded as essentially 'multi-component' interventions. Additional work is required in order to better characterize the essential or core components of each of the broad approaches to intervention. It is possible that the inclusion of studies on the basis of their use of discrete intervention techniques (for example, goal-setting, practice of structured tasks, and use of specific learning strategies such as errorless learning), rather than whether they fit neatly into the definitions offered here, will prove to be more informative.
Outcomes measured in included studies
A further issue impacting on the completeness and applicability of the evidence is the range of outcome measures reported in the included studies. Trials, particularly of cognitive training, have traditionally measured mainly cognitive outcomes in the form of performance on standardized cognitive measures. Very few studies, however, have measured non-cognitive outcomes for the person with dementia or the primary caregiver (for example, mood, quality of life, general health, and well-being) or outcomes that are likely to be of critical importance to policy-makers - such as outcomes related to the course of dementia (for example, dementia severity and rates of admission to residential care). Although there are obvious methodological constraints to the measurement of some outcomes (for example, long-term outcomes such as admission to residential care), it is nonetheless important that future trials of cognition-based interventions routinely measure and report outcomes other than direct cognitive ones. Given the nature and aims of individualized cognitive rehabilitation interventions, these tend to emphasize individualized goals and activities of daily living over performance on standardized cognitive tests. Indeed, the single trial of cognitive rehabilitation included in the present review measured and reported several important outcomes other than cognitive outcomes that are of direct clinical relevance.
Methodological limitations of included studies
The lack of significant effects from cognitive training studies must be interpreted in the context of methodological limitations that may have constrained the possibility of demonstrating some significant gains, including issues related to power, choice of control condition, choice of outcome measures, and the impact of individual characteristics that may moderate treatment response.
Power to detect effects
Many of the included trials are likely to have suffered from limited statistical power to detect effects. Lack of power of individual studies to detect effects is commonly associated with small sample size, which is a frequent limitation in cognition-based interventions for people with mild AD or VaD. This explanation, however, is un-likely to account for the lack of significant findings, as a meta-analysis is designed to overcome limitations from individual studies associated with such factors as sample size. Indeed, not only was the size of the effects in individual studies small, but - possibly of greater relevance here - the direction of effects associated with some outcomes did not consistently favor cognitive training over the control condition. For example, in three out of the five studies that reported the impact of cognitive training on a global measure of cognition in the short term, the direction of the effect was in favor of the control group, whereas in only one of the trials was the effect clearly in favor of the cognitive training condition. Indeed, such inconsistency in the direction of effects was the case for a substantial number of outcomes reported in the studies, even when the same measures were used by different studies to measure a given outcome. Other possible factors contributing to the difficulty in detecting significant effects might be difficulties in determining the right 'dose' of an intervention (that is, frequency, intensity, and duration of interventions), the presence of 'ceiling' or 'floor' effects rendering it impossible to demonstrate improvements in a given domain, or base-line differences between treatment and control groups.
Choice of control condition
The difficulty of defining what constitutes an appropriate comparison condition is particularly important since in some studies (for example, [16, 24]) cognitive training may have been compared with other active treatments, thus masking potentially beneficial effects. Clinical practice requires the ability to distinguish which of a range of possible psychosocial interventions is most likely to be useful for a given individual, and the study designs used here do not allow this question to be addressed.
Use of neuropsychological tests as cognitive outcomes
The use of neuropsychological tests to measure cognitive outcomes effectively means that what is actually being assessed is transfer of benefits from trained to untrained tasks, rather than the effects of training on trained tasks. However, as discussed in the introduction, there is very limited evidence in support of such transfer from trained to untrained tasks. But when the trained tasks are in some way analogous to daily activities, improvement in such tasks may have direct relevance to daily functioning, but this would be missed if these benefits were not transferred to performance on standardized neuropsychological tests. For example, Davis and colleagues  noted improvement on tasks during training, such as recall of personal information and face-name associations, but this was not captured by the neuropsychological measures selected to assess cognitive outcomes. A further problem with the use of standardized neuropsychological tests before and after the intervention to measure cognitive outcomes involves the potential for practice effects which may obscure possible effects of specific treatments. Finally, in some studies, more than one neuropsychological test or self-report scale is used to measure the same outcome (for example, executive function or general well-being). This leads to difficulties in meta-analysis with the choice of the most appropriate or relevant test as the measure of the outcome under consideration.
Moderating role of patient characteristics on intervention outcomes
There is an increasing recognition that various patient characteristics have the potential to moderate engagement with and response to the intervention, and as more evidence regarding important moderators becomes available, cognition-focused interventions might be better able to accommodate the effects of such moderators . For example, Koltai and colleagues  retrospectively classified participants' level of awareness of their own impairments and found that a higher level of awareness was a predictor of a more successful outcome, a finding that has also been demonstrated in a prospective study of cognitive rehabilitation outcome for a small group of people with mild AD .
Non-pharmacological interventions are more likely to be affected by the study context, including the health-care setting, and cultural and linguistic factors than drug trials are. Given that the studies reviewed took place in a variety of contexts, one cannot exclude the possibility that cognition-based interventions are better suited for some contexts than others.
Quality of the evidence
As discussed above, the generally low methodological quality of trials continues to limit the ability to evaluate the evidence base. The methodological quality is gradually improving, and this trend is expected to continue. The quality of most of the studies of cognitive training interventions included in the review was often compromised by several risks of bias that were significant in many of the included studies - particularly as a result of insufficient detail regarding the method used to generate a random group allocation sequence, the concealment of this sequence from relevant members of the research team, and attempts to blind participants or researchers (or both) to group allocation. Hence, the finding of no significant benefits (or harm) from cognitive training interventions needs to be interpreted with caution, and estimates of effect sizes may vary in the future as the evidence comes from studies of better quality. There was only a single study of individualized cognitive rehabilitation, but given the relatively high quality of this trial, cautiously positive (albeit tentative) conclusions regarding the efficacy of this approach can be drawn.
Agreements and disagreements with other studies or reviews
In recent years, two main systematic reviews that included an examination of the efficacy of cognitive training for people with mild dementia have been published. In reviewing the literature to 2004, Sitzer and colleagues  concluded that 'cognitive training evidenced promise in the treatment of AD, with primarily medium effect sizes for learning, memory, executive functions, activities of daily living, general cognitive problems, depression, and self-rated general functioning'. A closer examination of the methodology described in their review reveals important differences that explain the differences with the results of the present review. First, Sitzer and colleagues applied much less strict inclusion criteria and included both randomized and non-randomized trials (total of 19) as well as studies that included patients with moderate to severe AD. Second, Sitzer and colleagues described their review as one of cognitive training, but of the 14 RCTs that met their inclusion criteria, six were in fact studies of other cognition-based interventions (primarily reality orientation/cognitive stimulation) or multi-component interventions. Indeed, in separate analyses, performed on only the five 'high-quality' trials (all of which were included in the present review), the observed effects were very small and non-significant. It is quite plausible that if studies of cognitive stimulation, training, and rehabilitation for people with mild AD or VaD had been assessed together, some benefits would have been detected. However, as there are important differences between the different cognition-focused approaches to intervention, these should be treated separately. Indeed, although the present review did not observe any benefits associated with cognitive training, the results of a single high-quality trial of cognitive rehabilitation tentatively suggest that this approach may be associated with important benefits for the person with dementia and their primary caregiver. In addition, a separate Cochrane Review of cognitive stimulation for mild AD recently confirmed that this approach was associated with several positive outcomes for the person with dementia .
More recently, Olazarán and colleagues  reviewed the general literature on the efficacy of 26 categories of non-pharmacological interventions for people with dementia. In relation to cognitive training, these authors concluded that a grade B recommendation (recommendation associated with low-quality RCTs) can be given for the efficacy of individual and group cognitive training for improving cognitive functions. Although this conclusion also seems to be different from the results of the present review, there are important differences between this review and that by Olazarán and colleagues. Specifically, Olazarán and colleagues included in their review participants with any kind of dementia and in fact allowed a small proportion of participants with cognitive decline but without confirmed dementia to be included. In addition, these authors did not examine separate cognitive domains, but instead analyzed all cognitive outcomes together, and this was not the approach taken in the present review. These methodological differences most likely account for the differences between the present review and the one by Olazarán and colleagues.
Implications for research
Further well-designed single-blind RCTs of cognitive training would help to provide more definitive evidence regarding efficacy. Future research would benefit from consideration of how to capture changes that are currently missed by the available standardized outcome measures, from development of greater consensus in the selection of specific outcome measures, and from identification of the extent to which gains are clinically relevant and generalizable and have the potential to make a difference to the person with dementia and the family caregiver in everyday life. Future research should continue the trend toward devising interventions that include personalized tasks or tasks based on analogs of daily activities. Future research also needs to consider outcomes beyond direct cognitive ones, to describe in greater detail the elements of the intervention used (preferably by using manualized protocols), and to more accurately use existing classifications of cognition-based interventions.
Additional RCTs of individualized cognitive rehabilitation are needed in order to provide further support for tentatively promising results.
Implications for clinical practice
The review does not provide evidence to support the efficacy of cognitive training. Trial reports indicate that some gains resulting from intervention may not be captured adequately by available standardized outcome measures.
Data from a single high-quality trial provide preliminary positive results regarding the use of contextualized individual cognitive rehabilitation, emphasizing collaborative goal-setting, to achieve better self-rated competence and satisfaction with personally meaningful activities of daily living. Risk of harm or adverse effects of cognitive rehabilitation is unlikely. The capacity to make firmer treatment recommendations awaits the publication of additional trials of individual cognitive rehabilitation.
This is a version of a Cochrane Review, which is available in the Cochrane Library. Cochrane systematic reviews are regularly updated to include new research and in response to feedback from readers. If you have a comment on this or other Cochrane Reviews of interventions for AD or VaD, please send it to Sue Marcus, editor of the Cochrane Dementia and Cognitive Improvement Group (firstname.lastname@example.org).
Cochrane Database of Systematic Reviews
functional magnetic resonance imaging
mild cognitive impairment
randomized controlled trial
AB-F is supported by funding from the Dementia Collaborative Research Centre-Early Detection and Prevention and would like to acknowledge the support of the Rosemary Foundation Travel Fellowship awarded to him by the Alzheimer's Australia Research Foundation.
- Reifler BV, Larson E: Excess disability in dementia of the Alzheimer's type. Alzheimer's Disease Treatment and Family Stress: Directions for Research. Edited by: Light E, Liebowitz B. 1990, New York: Hemisphere
- Salomone S, Caraci F, Leggio GM, Fedotova J, Drago F: New pharmacological strategies for treatment of Alzheimer's disease: focus on disease modifying drugs. Br J Clin Pharmacol. 2012, 73: 504-517. 10.1111/j.1365-2125.2011.04134.x.PubMed CentralView ArticlePubMed
- Small GW, Rabins PV, Barry PP, Buckholtz NS, DeKosky ST, Ferris SH, Finkel SI, Gwyther LP, Khachaturian ZS, Lebowitz BD, McRae TD, Morris JC, Oakley F, Schneider LS, Streim JE, Sunderland T, Teri LA, Tune LE: Diagnosis and treatment of Alzheimer disease and related disorders: consensus statement of the American Association for Geriatric Psychiatry, the Alzheimer's Association and the American Geriatric Society. JAMA. 1997, 278: 1363-1371. 10.1001/jama.1997.03550160083043.View ArticlePubMed
- Woods RT, Clare L: Cognition-based therapies and mild cognitive impairment. Perspectives on Mild Cognitive Impairment. International Perspectives. Edited by: Tuokko H, Hultsch D. 2006, New York: Taylor & Francis, 245-264.
- Woods B, Aguirre E, Spector AE, Orrell M: Cognitive stimulation to improve cognitive functioning in people with dementia. Cochrane Database Syst Rev. 2012, 2: CD005562-PubMed
- Clare L, Woods RT, Moniz-Cook ED, Orrell M, Spector A: Cognitive rehabilitation and cognitive training for early-stage Alzheimer's disease and vascular dementia. Cochrane Database Syst Rev. 2003, CD003260-
- Clare L, Woods RT: Cognitive training and cognitive rehabilitation for people with early-stage Alzheimer's disease: a review. Neuropsychol Rehabil. 2004, 14: 385-401. 10.1080/09602010443000074.View Article
- Clare L: Cognitive training and cognitive rehabilitation for people with early-stage dementia. Rev Clin Gerontol. 2003, 13: 75-83.View Article
- Quayhagen MP, Quayhagen M, Corbeil RR, Roth PA, Rodgers JA: A dyadic remediation program for care recipients with dementia. Nurs Res. 1995, 44: 153-159.View ArticlePubMed
- Davis RN, Massman PJ, Doody RS: Cognitive intervention in Alzheimer disease: a randomized placebo-controlled study. Alzheimer Dis Assoc Disord. 2001, 15: 1-9. 10.1097/00002093-200101000-00001.View ArticlePubMed
- de Vreese LP, Neri M, Fioravanti M, Belloi L, Zanetti O: Memory rehabilitation in Alzheimer's disease: a review of progress. Int J Geriatr Psychiatry. 2001, 16: 794-809. 10.1002/gps.428.View ArticlePubMed
- Heiss WD, Kessler J, Slansky I, Mielke R, Szelies B, Herholz K: Activation PET as an instrument to determine therapeutic efficacy in Alzheimer's disease. Ann N Y Acad Sci. 1993, 695: 327-331. 10.1111/j.1749-6632.1993.tb23078.x.View ArticlePubMed
- Schreiber M, Schweizer A, Lutz K, Kalveram KT, Jäncke L: Potential of an interactive computer-based training in the rehabilitation of dementia: an initial study. Neuropsychol Rehabil. 1999, 9: 155-167. 10.1080/713755596.View Article
- Galante E, Venturini G, Fiaccadori C: Computer-based cognitive intervention for dementia: preliminary results of a randomized clinical trial. G Ital Med Lav Ergon. 2007, 29: 26-32.
- Zanetti O, Zanieri G, di Giovanni G, de Vreese LP, Pezzini A, Metitieri T, Trabucchi M: Effectiveness of procedural memory stimulation in mild Alzheimer's disease patients: a controlled study. Neuropsychol Rehabil. 2001, 11: 263-272. 10.1080/09602010042000088.View Article
- Loewenstein DA, Acevedo A, Czaja SJ, Duara R: Cognitive rehabilitation of mildly impaired Alzheimer disease patients on cholinesterase inhibitors. Am J Geriatric Psychiatry. 2004, 12: 395-View Article
- Neely AS, Vikstrom S, Josephsson S: Collaborative memory intervention in dementia: caregiver participation matters. Neuropsychol Rehabil. 2009, 19: 696-715. 10.1080/09602010902719105.View ArticlePubMed
- Peretz C, Korczyn AD, Shatil E, Aharonson V, Birnboim S, Giladi N: Computer-based, personalized cognitive training versus classical computer games: a randomized double-blind prospective trial of cognitive stimulation. Neuroepidemiology. 2011, 36: 91-99. 10.1159/000323950.View ArticlePubMed
- Owen AM, Hampshire A, Grahn JA, Stenton R, Dajani S, Burns AS, Howard RJ, Ballard CG: Putting brain training to the test. Nature. 2010, 465: 775-778. 10.1038/nature09042.PubMed CentralView ArticlePubMed
- Papp KV, Walsh SJ, Snyder PJ: Immediate and delayed effects of cognitive interventions in healthy elderly: a review of current literature and future directions. Alzheimers Dement. 2009, 5: 50-60. 10.1016/j.jalz.2008.10.008.View ArticlePubMed
- Jaeggi SM, Studer-Luethi B, Buschkuehl M, Su YF, Jonides J, Perrig WJ: The relationship between n-back performance and matrix reasoning - implications for training and transfer. Intelligence. 2010, 38: 625-635. 10.1016/j.intell.2010.09.001.View Article
- Gates N, Sachdev P, Singh MF, Valenzuela M: Cognitive and memory training in adults at risk of dementia: a systematic review. BMC Geriatr. 2011, 11: 55-10.1186/1471-2318-11-55.PubMed CentralView ArticlePubMed
- Koltai DC, Welsh-Bohmer KA, Smechel DE: Influence of anosognosia on treatment outcome among dementia patients. Neuropsychol Rehabil. 2001, 11: 455-475. 10.1080/09602010042000097.View Article
- Cahn-Weiner DA, Malloy PF, Rebok GW, Ott BR: Results of a placebo-controlled study of memory training for mildly-impaired Alzheimer's Disease patients. Appl Neuropsychol. 2003, 10: 215-223. 10.1207/s15324826an1004_3.View ArticlePubMed
- Quayhagen MP, Quayhagen M, Corbeil RR, Hendrix RC, Jackson JE, Snyder L, Bower D: Coping with dementia: evaluation of four nonpharmacologic interventions. Int Psychogeriatr. 2000, 12: 249-265. 10.1017/S1041610200006360.View ArticlePubMed
- Newhouse PA, Potter A, Levin ED: Nicotinic system involvement in Alzheimer's and Parkinson's diseases: implications for therapeutics. Drugs Aging. 1997, 11: 206-228. 10.2165/00002512-199711030-00005.View ArticlePubMed
- Yesavage JA, Westphal J, Rush L: Senile dementia: combined pharmacologic and psychologic treatment. J Am Geriatr Soc. 1981, 29: 164-171.View ArticlePubMed
- Brodaty H, Gresham M, Luscombe G: The Prince Henry Hospital dementia caregivers' training programme. Int J Geriatr Psychiatry. 1997, 12: 183-192. 10.1002/(SICI)1099-1166(199702)12:2<183::AID-GPS584>3.0.CO;2-J.View ArticlePubMed
- McLellan DL: Functional recovery and the principles of disability medicine. Clinical Neurology. Edited by: Swash M. 1991, London: Churchill Livingstone, 768-790.
- World Health Organization: International Classification of Functioning, Disability and Health (ICF). [http://www.who.int/classifications/icf/en/]
- Koehler R, Wilhelm E, Shoulson I: Cognitive Rehabilitation Therapy for Traumatic Brain Injury Cognitive Rehabilitation Therapy for Traumatic Brain Injury: Evaluating the Evidence. 2011, Washington, DC: The National Academies Press
- Wilson BA: Towards a comprehensive model of cognitive rehabilitation. Neuropsychol Rehabil. 2002, 12: 97-110. 10.1080/09602010244000020.View Article
- Ylvisaker M, Hanks R, Johnson-Greene D: Perspectives on rehabilitation of individuals with cognitive impairment after brain injury: rationale for reconsideration of theoretical paradigms. J Head Trauma Rehabil. 2002, 17: 191-209. 10.1097/00001199-200206000-00002.View ArticlePubMed
- Rabipour S, Raz A: Training the brain: Fact and fad in cognitive and behavioral remediation. Brain Cogn. 2012, 79: 159-179. 10.1016/j.bandc.2012.02.006.View ArticlePubMed
- Belleville S, Clément F, Mellah S, Gilbert B, Fontaine F, Gauthier S: Training-related brain plasticity in subjects at risk of developing Alzheimer's disease. Brain. 2011, 134: 1623-10.1093/brain/awr037.View ArticlePubMed
- Christensen H, Kopelman MD, Stanhope N, Lorentz L, Owen P: Rates of forgetting in Alzheimer dementia. Neuropsychologia. 1998, 36: 547-557. 10.1016/S0028-3932(97)00116-4.View ArticlePubMed
- Kopelman MD: Rates of forgetting in Alzheimer-type dementia and Korsakoff's syndrome. Neuropsychologia. 1985, 23: 623-638. 10.1016/0028-3932(85)90064-8.View ArticlePubMed
- Little AG, Volans PJ, Hemsley DR, Levy R: The retention of new information in senile dementia. Br J Clin Psychol. 1986, 25: 71-72. 10.1111/j.2044-8260.1986.tb00673.x.View ArticlePubMed
- Bäckman L: Utilizing compensatory task conditions for episodic memory in Alzheimer's disease. Acta Neurologica Scandinavica. 1996, 109-113. suppl 165
- Camp CJ, Bird MJ, Cherry KE: Retrieval strategies as a rehabilitation aid for cognitive loss in pathological aging. Cognitive Rehabilitation in Old Age. Edited by: Hill RD, Backman L, Stigsdotter-Neely A. 2000, Oxford: Oxford University Press
- Clare L, Wilson BA, Breen K, Hodges JR: Errorless learning of face-name associations in early Alzheimer's disease. Neurocase. 1999, 5: 37-46. 10.1080/13554799908404063.View Article
- Clare L, Wilson BA, Carter G, Roth I, Hodges JR: Relearning of face-name associations in early-stage Alzheimer's disease. Neuropsychology. 2002, 16: 538-547.View ArticlePubMed
- Anderson J, Arens K, Johnson R, Coppens P: Spaced retrieval vs memory tape therapy in memory rehabilitation for dementia of the Alzheimer's type. Clin Gerontol. 2001, 24: 123-139. 10.1300/J018v24n01_09.View Article
- Josephsson S, Backman L, Borell L, Bernspang B, Nygard L, Ronnberg L: Supporting everyday activities in dementia: an intervention study. Int J Geriatr Psychiatry. 1993, 8: 395-400. 10.1002/gps.930080505.View Article
- Clare L, Wilson BA, Carter G, Breen K, Gosses A, Hodges JR: Intervening with everyday memory problems in dementia of Alzheimer type: an errorless learning approach. J Clin Exp Neuropsychol. 2000, 22: 132-146. 10.1076/1380-3395(200002)22:1;1-8;FT132.View ArticlePubMed
- Dunn J, Clare L: Learning face-name associations in early-stage dementia: comparing the effects of errorless learning and effortful processing. Neuropsychol Rehabil. 2007, 17: 735-754. 10.1080/09602010701218317.View ArticlePubMed
- Brandt J, Rich JB: Memory disorders in the dementias. Handbook of Memory Disorders. Edited by: Baddeley AD, Kopelman MD, Wilson BA. 1995, Chichester: John Wiley & Sons Ltd
- Morris RG: The neuropsychology of Alzheimer's disease and related dementias. Handbook of the Clinical Psychology of Ageing. Edited by: Woods R, Clare L. 1996, Chichester: John Wiley & Sons Ltd
- Kurlychek RT: Use of a digital alarm chronograph as a memory aid in early dementia. Clin Gerontol. 1983, 1: 93-94.
- Bourgeois MS: Evaluating memory wallets in conversations with persons with dementia. J Speech Hear Res. 1992, 35: 1344-1357.View ArticlePubMed
- Bird M: Behavioural difficulties and cued recall of adaptive behaviour in dementia: experimental and clinical evidence. Neuropsychol Rehabil. 2001, 11: 357-375. 10.1080/09602010042000042.View Article
- ALOI S: a comprehensive register of dementia studies. [http://www.medicine.ox.ac.uk/alois/]
- Higgins JPT, Altman DG, Sterne JAC: Chapter 8: Assessing risk of bias in included studies. Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0. Edited by: Higgins JPT. 2011, Oxford, UK: The Cochrane Collaboration, (updated March 2011)
- Clare L, Linden DE, Woods RT, Whitaker R, Evans SJ, Parkinson CH, van Paasschen J, Nelis SM, Hoare Z, Yuen KS, Rugg MD: Goal-oriented cognitive rehabilitation for people with early-stage Alzheimer disease: a single-blind randomized controlled trial of clinical efficacy. Am J Geriatr Psychiatry. 2010, 18: 928-939. 10.1097/JGP.0b013e3181d5792a.View ArticlePubMed
- Beck C, Heacock P, Mercer S, Thatcher R: The impact of cognitive skills remediation training on persons with Alzheimer's disease or mixed dementia. J Geriatr Psychiatry. 1988, 21: 73-88.PubMed
- De Vreese L, Verlato C, Emiliani S, Schioppa S, Belloi L, Salvioli G, Neri M: Effect size of a three-month drug treatment in AD when combined with individual cognitive retraining: preliminary results of a pilot study. Neurobiol Aging. 1998, 19: S213-
- Heiss WD, Kessler J, Mielke R, Szelies B: Long-term effects of phosphatidylserine, pyritinol, and cognitive training in Alzheimer's disease: a neuropsychological, EEG, and PET investigation. Dementia. 1994, 5: 88-98.PubMed
- van Paasschen J, Clare L, Yuen KS, Woods RT, Evans SJ, Parkinson CH, Rugg MD, Linden DE: Cognitive rehabilitation changes memory-related brain activity in people with Alzheimer disease. Neurorehabil Neural Repair. 2013, 27: 448-459. 10.1177/1545968312471902.View ArticlePubMed
- Bentwich J, Dobronevsky E, Aichenbaum S, Shorer R, Peretz R, Khaigrekht M, Marton RG, Rabey JM: Beneficial effect of repetitive transcranial magnetic stimulation combined with cognitive training for the treatment of Alzheimer's disease: a proof of concept study. J Neural Transm. 2011, 118: 463-471. 10.1007/s00702-010-0578-1.View ArticlePubMed
- Hwang HR, Choi SH, Yoon DH, Yoon BN, Suh YJ, Lee D, Han IT, Hong CG: The effect of cognitive training in patients with mild cognitive impairment and early Alzheimer's disease: a preliminary study. J Clin Neurol. 2012, 8: 190-197. 10.3988/jcn.2012.8.3.190.PubMed CentralView ArticlePubMed
- Kurz A, Thöne-Otto A, Cramer B, Egert S, Frölich L, Gertz HJ, Kehl V, Wagenpfeil S, Werheid K: CORDIAL: Cognitive rehabilitation and cognitive-behavioral treatment for early dementia in alzheimer disease: a multicenter, randomized, controlled trial. Alzheimer Dis Assoc Disord. 2012, 26: 246-253. 10.1097/WAD.0b013e318231e46e.View ArticlePubMed
- Graff MJ, Vernooij-Dassen MJ, Thijssen M, Dekker J, Hoefnagels WH, Rikkert MG: Community based occupational therapy for patients with dementia and their care givers: randomised controlled trial. BMJ. 2006, 333: 1196-10.1136/bmj.39001.688843.BE.PubMed CentralView ArticlePubMed
- Albert MS, DeKosky ST, Dickson D, Dubois B, Feldman HH, Fox NC, Gamst A, Holtzman DM, Jagust WJ, Petersen RC, Snyder PJ, Carrillo MC, Thies B, Phelps CH: The diagnosis of mild cognitive impairment due to Alzheimer's disease: Recommendations from the National Institute on Aging and Alzheimer's Association workgroup. Alzheimers Dement. 2011, 7: 270-279. 10.1016/j.jalz.2011.03.008.PubMed CentralView ArticlePubMed
- Gauthier S, Reisberg B, Zaudig M, Petersen RC, Ritchie K, Broich K, Belleville S, Brodaty H, Bennett D, Chertkow H, Cummings JL, de Leon M, Feldman H, Ganguli M, Hampel H, Scheltens P, Tierney MC, Whitehouse P, Winblad B, International Psychogeriatric Association Expert Conference on mild cognitive impairment: Mild cognitive impairment. Lancet. 2006, 367: 1262-1270. 10.1016/S0140-6736(06)68542-5.View ArticlePubMed
- Jean L, Bergeron MÈ, Thivierge S, Simard M: Cognitive intervention programs for individuals with mild cognitive impairment: systematic review of the literature. Am J Geriatr Psychiatry. 2010, 18: 281-296. 10.1097/JGP.0b013e3181c37ce9.View ArticlePubMed
- Martin M, Clare L, Altgassen AM, Cameron MH, Zehnder F: Cognition-based interventions for healthy older people and people with mild cognitive impairment. Cochrane Database Syst Rev. 2011, CD006220-1
- Reeves BC, Deeks JJ, Higgins JPT, Wells GA: Chapter 13: Including non-randomized studies. Cochrane Handbook for Systematic Reviews of Interventions Version 510 (updated March 2011). Edited by: Higgins JPT. 2011, Oxford, UK: The Cochrane Collaboration
- Giordano M, Dominguez LJ, Vitrano T, Curatolo M, Ferlisi A, Di Prima A, Belvedere M, Barbagallo M: Combination of intensive cognitive rehabilitation and donepezil therapy in Alzheimer's disease (AD). Arch Gerontol Geriatr. 2010, 245-249.
- Choi J, Twamley EW: Cognitive rehabilitation therapies for Alzheimer's disease: a review of methods to improve treatment engagement and self-efficacy. Neuropsychol Rev. 2013, 23: 48-62. 10.1007/s11065-013-9227-4.PubMed CentralView ArticlePubMed
- Clare L, Wilson BA, Carter G, Roth I, Hodges JR: Awareness in early-stage Alzheimer's disease: relationship to outcome of cognitive rehabilitation. J Clin Exp Neuropsychol. 2004, 26: 215-226. 10.1076/jcen.22.214.171.124088.View ArticlePubMed
- Sitzer D, Twamley E, Jeste D: Cognitive training in Alzheimer's disease: a meta-analysis of the literature. Acta Psychiatr Scand. 2006, 114: 75-90. 10.1111/j.1600-0447.2006.00789.x.View ArticlePubMed
- Olazarán J, Reisberg B, Clare L, Cruz I, Peña-Casanova J, Del Ser T, Woods B, Beck C, Auer S, Lai C, Spector A, Fazio S, Bond J, Kivipelto M, Brodaty H, Rojo JM, Collins H, Teri L, Mittelman M, Orrell M, Feldman HH, Muñiz R: Nonpharmacological therapies in Alzheimer's disease: a systematic review of efficacy. Dement Geriatr Cogn Disord. 2010, 30: 161-178. 10.1159/000316119.View ArticlePubMed